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DNA-UTAH.ORG is the noncommercial continuation of dna.utah.edu, a repository of molecular techniques and software tools that were generated by 30 years of academic research by Carl T. Wittwer whose passion is to make nucleic acid analysis faster and better. While the the physical laboratory closed in 2020 with the retirement of Dr. Carl Wittwer, we continue to provide updates to PCR techniques and analytical software. DNA-UTAH.ORG is funded by Crestwood Technology (Maine, USA) and continues to explore collaborative projects. Get to know Carl T. Wittwer, MD, PhDQuick Facts  Quick Bio
Dr. Carl Wittwer is Professor Emeritus of Pathology at the University of Utah. He received a Ph.D. from Utah State University, and an M.D. from the University of Michigan. Carl has published extensively on technique and instrument development in molecular diagnostics. In the early 1990s he developed rapid-cycle PCR allowing DNA amplification in 10-15 min. In the mid-1990s, he adapted flow cytometry optics to thermal cycling for real-time monitoring of PCR. He introduced SYBR Green I, adjacent hybridization probes, melting analysis, and high-resolution melting (HRM) to real-time PCR, techniques that are widely used today. He has been on the Clinical Chemistry Board of Editors since 2000 and an Associate Editor since 2002. He served as Chairman of the Board for BioFire from 2012 until its acquisition by BioMerieux in 2014. He is the primary inventor of the LightCycler system, with over 10,000 units placed worldwide by Roche.
Interviews & EditorialsPodcast 2018 Editorial 2015 TechVentures 2012 Inspiring Minds 2009 BioTalk 2009 QuotesKary B. Mullis, in the preface to, The Polymerase Chain Reaction, Springer Science and Business, 1994, page xi: “Few, strictly methodological people are working with DNA. A refreshing exception is Carl Wittwer, from, strangely enough, the Pathology Department at Utah Medical School. I would have thought, Chemical Engineering at Cal Tech, but I knew otherwise. If I were you, I would read his paper, or have someone more technically competent explain it. Carl has thought about PCR in a way that very few others have, and his thoughts are crisp and practical. I have always known that a good physiochemical description of PCR would be very useful, but deriving one was over my head. Others have tried but not succeeded…”” W. Edward Highsmith, Jr, in an editorial for Clinical Chemistry, 2004;50:1296-1298: “Dr. Wittwer and his colleagues have pioneered rapid, affordable mutation-detection technology and have moved these developments out of the engineering laboratory and into the clinical laboratory. Looking to the future, I can hardly wait to see what the Wizard of Salt Lake will come up with next.” Stephen A. Bustin, in the preface to, The PCR Revolution; Basic Technologies and Applications, Cambridge University Press, 2010, page xiv: “Contributors include giants of the PCR field: Carl Wittwer, the ‘father’ of qPCR instrumentation as well the pacesetter behind numerous practical qPCR innovations…” The Pathologist Power List 2015 listed in The Pathologist 13;29:2015. "Described as a pioneer in nucleic acid analysis, Carl invented a number of key polymerase chain reaction technologies that are now used worldwide.” | |||||||||||||
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